Endocrine Abstracts

Introduction: The improvement of vitamin D status is necessary to overcome an impaired calcium-phosphorus metabolism and disturbances in other tissues functioning; safety of medical intervention should include analysis of metabolic changes.Material and methods: Twenty four apparently healthy volunteers 24.9±2 year were included in the study: Group 1 (11/24) with blood serum levels of 25(OH)D <10 ng/ml and Group 2 (13/24) with 25(OH)D levels 10&#...

Introduction: Long term remission of CD is achieved in 65–83% after neurosurgery, while the remaining cases have recurrence or continued tumor growth. This paper deals with the problem of CD prognostic factors after neurosurgery.Design: ACTH and cortisol blood levels, free cortisol in daily urine, MRI, histology (hemotaxiline–eosine staining) and immunohistochemistry (with antibodies to the pituitary tropic hormones, Ki-67, CD31 and VEGF) of th...

MEN1 syndrome is an autosomal dominant inherited disease characterised by primary hyperparathyroidism in association with endocrine enteropancratic tumors and anterior pituitary adenomas. Tumours of the pituitary gland as the first manifestations of MEN1 are very rare in children.Clinical case report: A 13-year-old boy presented with clinical signs suggestive of Cushing’s syndrome. He had decreased growth rate, muscle weakness, headaches and truncal...

Introduction: Cushing’s disease (CD) is associated with persistent risk of cardiovascular complications, which were found to be four times higher than in age- and sex-matched population. The main cause is cardiovascular disease with thrombotic complications due to the activation of changes in haemostatic and fibrinolytic system with high level of cortisol secretion.Objective: To study hemostatic and fibrinolytic state in patients with CD.<p clas...

Introduction: Chronic endogenous hypercortisolism is characterized by abdominal obesity, systemic arterial hypertension, glucose and lipid abnormalities, insulin resistance, osteoporosis. This syndrome also has features of hypercoagulation. The mortality rate in patients with active Cushing’s disease (CD) is four times higher than in age- and sex- matched population. The main cause is cardiovascular disease with thrombotic complications.Objective: T...

Aim: To access the efficiency of mulitispine computed tomography (MSCT) in ectopic ACTH-syndrome.Patients and methods: Five clinical cases (2 female and 3 male cases) with severe hypercortisolism were analyzed, age from 26 to 63 years old.Results: In all of the 5 cases there were significant reasons to suppose ectopic ACTH-syndrome: rapid development of clinical features (in 4 of 5 cases), loss of lean mass compound with rounded an...

Objectives: To evaluate predictors of permanent, transient and three-phase diabetes insipidus (DI) in patients undergoing endoscopic endonasal transsphenoidal surgery.Patients and methods: The study included 154 patients undergoing endoscopic endonasal transsphenoidal surgery (122 women and 32 men) age from 18 to 65 years (median 40 (31;52)). 73 patients with Cushing disease, 66 patients with acromegaly, four patients with prolactinomas, nine patients wi...

Phaeochromocytomas are responsible for the development ACTH-ectopic syndrome in 5% cases. Less than 1% phaeochromocytoma accompanied by symptoms of ACTH-dependent hypercortisolism. We observed four cases of ACTH-secreting phaeochromocytoma during 2 years. All patients were women from 50 to 63 years. The disease duration ranged from 6 months to 5 years. The clinical picture presented the signs of hypercortisolism (matronism, hyperpigmentation of the skin, the redistribution of ...

Abstract: Transsphenoidal surgery is the treatment of choice for Cushing’s disease. Despite the 70–90% remission rates relapses after successful transnasal adenectomy are frequently observed.Aim: To evaluate the dynamics of intra- and early postoperative levels of adrenocorticotrophic hormone (ACTH) and cortizol and their role as predictors or Cushing’s disease remission.Materials/methods: Fifty patients with Cushing...

Background: It is known women suffer from macroprolactinaemia more frequently than men. Often men with unclear genesis of hyperprolactinaemia have normal or a little depressed Testosterone level. High macroprolactin level in blood serum can explain this type of hyperprolactinaemia.Materials and methods: Sixty-four men with hyperprolactinaemia (Prl >600 mU/l) were studied. Clinical, biochemical and MRI methods were used. Prl and Testosterone levels we...